May 27, 2017

Supplementing for Stress + Setria® Glutathione

Supplementing for Stress + Setria® Glutathione

Thank you so much to Kyowa Hakko for sponsoring this post. I wouldn’t be able to spend such mindful time and energy on researching topics I love without the support of brands I love.

A few weeks back, I was suddenly consumed with a fit of sneezes and sniffles. I first assumed I had contracted the dreaded spring / summer cold, but this attack directly paralleled when the grass was just cut. The stirring of the lawn and pollen somehow infiltrated my nostrils, and they were, simply put, just not having it. The entire day was agony and my nose mimicked that of a Puffs commercial by the end – raw, red, and Rudolph the Reindeer in appearance.

For the few weeks surrounding this time, my stress and responsibilities had skyrocketed. I was (and am) trying to juggle an enormous research paper, cumulative 2 year exam, blogging, interning, making it to dance rehearsals, and moving. Safe to say I am coddling stress like a small child, and I haven’t been doing the best at juggling on time with off time – kind of like in a constant state of fight of flight.

My immune system, therefore, has taken an obvious plummet, and with this comes a stressed out gut due to something called the gut-brain axis. According to Campbell ( 1 ), the gut-brain axis “acts as a bidirectional communication between the brain and the gut.” This signaling is regulated at neural, hormonal and immunological levels and is vital for homeostasis and balance ( 2 ). The brain modulates gastrointestinal function and vice versa, and the intestinal microbiota play a role in the development and function of the enteric nervous system ( 1 ). The enteric nervous system, in fact, is even referred to as the “second brain”.

So things are all connected – brain, immunity and intestines, and from there – neural, hormonal, and even detoxification systems. That insidious little stress can really wreak its havoc on just about every aspect of the body, thereby decreasing immunity, defense, and psychological wellbeing.

So what is there to do?


  • Focus on antioxidant and flavonoid rich foods and drink: leafy greens, organic produce, goji berries, wild blueberries, dark chocolate, pecans, artichokes, elderberries, kidney beans, cranberries, black berries, cilantro, citrus fruits, apples, onions, parsley, sage, tea, and red wine, olive oil, grapes, dark cherries, and dark berries such as blueberries, blackberries, and bilberries
  • Eat a whole foods diet with lots of omega-3s, good sources of protein, ample fiber, prebiotics, probiotics, and low-inflammatory, low glycemic load foods
    • high omega-3 (eat): salmon, flax seed, chia seeds, sardines, cod liver, walnuts, bone broth, fatty fish, pasture raised meats / eggs)
    • foods that support good gut health – sauerkraut, kefir, kombucha, sweet potatoes, beetroot, lentils, chickpeas, kidney beans (find a full list here)
    • high omega-6 (avoid): vegetable oils, grapes oil, sunflower oil, canola oil, mayonnaise, soybean oil, safflower oil, margarine, shortening)
    • also avoid: refined polyunsaturated oils, fake fats, refined sugars, high fructose corn syrup, refined carbohydrates, artificial sweeteners, food toxins and genetically engineered foods
  • Make sure you’re supporting your detox systems: foods that support detoxification pathways: broccoli, cauliflower, cabbage, kale, brussels sprouts, radish sprouts, broccoli sprouts, allum vegetables (onions, leeks, garlic), chlorella, turmeric


  • 4, 7, 8 breathing for relief during moments of overwhelming stress: exhale completely, breath in for four counts, hold your breath for seven, then exhale completely through your mouth for 8 counts.
  • lean on social connections: Good social support is a positive influence on stress measures ( 3 ). Having just 3 regular social contacts is associated with lower stress scores. Repeat for a total of four times. This exercise stimulates the parasympathetic nervous system, in turn serving as a pseudo tranquilizer. This is also helpful when trying to fall asleep.
  • practice yoga
  • exercise
  • meditate
  • sleep
  • more suggestions here


    • Take a good probiotic and enhance your gut health (read more about the one I take here)
    • Incorporate adaptogens like reishi, cordyceps, and ashwagandha for stress response (read more about these in my post about stress)
    • Take an omega-3 to reduce inflammation and boost brain power
    • Try taking glutathione

I want to now transition into a new supplement I’m taking called glutathione made by Setria® Glutathione.

Glutathione (GSH) is the major antioxidant involved in cellular oxidative defense in the body ( 4 ). Its role in the body is to scavenge up reactive oxygen species (the extremely inflammatory molecules that lead to aging and overall disease and decline), as well as detoxify other reactive products, and maintains the status of proteins. Glutathione also regulates critical cellular processes like DNA synthesis and immune function ( 4 ).

I’ve learned a lot about this molecule in my classes, and it’s a supplement used in many protocols, including: detoxification, immunity, and inflammation. This is because it has diverse effects on the immune system, either stimulating or inhibiting the immunological response in order to control inflammation. It is present in all mammalian tissues as the most abundant non-protein molecule that defends against oxidative stress, and is a vital player in redox signaling, foreign substance detoxification, cell multiplication regulation, cell death, immune function, and fibrogenesis ( 5 ).

Foods like onion extract and quercetin naturally enhance this molecule due to their flavonoid content, but sometimes dietary sources aren’t enough when lifestyle choices (e.g. poor diet, stress, smoking, infection, disease, exposure to heavy metals) have wreaked their havoc ( 6 ). A western diet, in fact, is linked fatty liver, which places a burden on the liver. The liver is a major controller of glutathione synthesis in organs, and in one study done on mice, a western diet resulted in the altered liver glutathione metabolism due to the fact that there was a deceased glutathione redox ratio ( 4 ).

Older studies previously have shown taking a glutathione supplement doesn’t in fact lead to increased levels of cellular glutathione, but this has seen to be false as glutathione does indeed increase body stores of glutathione.

Setria® Glutathione is a tripeptide form of the molecule, that has in fact been clinical shown to raise blood glutathione levels. After three months of taking 1000mg of Setria® Glutathione, there was a 2 fold increase in NK cell activity (you need these for immune defense), as well as a 30% increase in whole blood, 35% increase in red blood cells and a 260% increase in buccal cells glutathione levels ( 7 ).

Beyond its clinical and studied efficacy, I also love Setria® Glutathione, because it is:

  • Produced by a patented, fermentation process
  • Contains no additives, artificial flavors or preservatives
  • Has no animal origin material (vegetarian)
  • Meets specification for the new USP monograph (USP)
  • Meets specification for The Japanese Pharmacopoeia (JP)
  • No TSE/BSE risk
  • GMP-compliant manufacturing
  • Allergen-free
  • Kosher

Furthermore, I love Healthy Origins brand containing Setria® Glutathione as the supplement does not contain any salt, starch, yeast, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, trees nuts, egg, or dairy, and has no artificial sweeteners or colors, and is manufactured in good old Pittsburgh, Pennsylvania. Totally allergen friendly, no unnecessary allergies, and based in the USA. (I hope you can feel the exclamation points rocketing out of my fingers at this point).

In conclusion, Setria® Glutathione can support: immune health, detoxification, skin health, and sports performance.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


( 1 ) Campbell, A.W. (2014). Autoimmunity and the gut. Autoimmune Disease (2014), 152428. doi: 10.1155/2014/152428

( 2 ) Grenham, S., Clarke, G., Cryan, J.F., & Dinan, T.G. (2011). Brain-gut-microbe communication in health and disease. Frontiers in Physiology. doi: 10.3389/fphys.2011.00094

( 3 ) McEwen, B.S. (2008). Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. European Journal of Pharmacology, 583(2-3), 174-185. doi: 10.1016/j.ejphar.2007.11.071

( 4 ) Li, L., Zhang, G-F., Lee, K., Lopez, R., Previs, S.F., Willard, B., McCullough, A., & Kasumov, T. (2016). A western diet induced NAFLD in LDLR-/- mice is associated with reduced hepatic glutathione synthesis. Free Radical Biology and Medicine, 96, 13-21. doi: 10.1016/j.freeradbiomed.2016.03.032

( 5 ) Lu, S.C. (2013). Glutathione synthesis. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, 1830(5), 3143-3153. doi: 10.1016/j.bbagen.2012.09.008

( 6 ) Myhrstad, M.C.W., Carlsen, H., Nordstrom, O., Blomhoff, r., & Moskaug, J.O. Flavonoids increase the intracellular glutathione level by transactivation of the y-glutamylcysteine syntheses catalytic subunit promoter. Free Radical Biology & Medicine, 32(5), 386-393.

( 7 ) Richie, J.P., Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J.S., Schell, T.D., Muscat, J.E. (2014). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition, 54(2), 251-263. doi: 10.1007/s00394-014-0706-z

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  • hope

    2015 me and my husband suffered from LUPUS(chronic autoimmune disease). it happened a few months after i got married to my husband. i found out that i got LUPUS and i was confirm positive and was perplexed, so angry and then i had to convince my husband to go test himself and when he did, he was also found positive and then it was dawn completely on me that me and my husband is having LUPUS . i went out in search of a solution despite my doctor told me that there was no remedy to curing me and my husband LUPUS . When i was searching, i found out there so many testimonies about perfect health herbal medicine home helping others to be cured of LUPUS (chronic autoimmune disease) . I instantly write down their email and purchase herbal medicine for lupus (chronic autoimmune disease),then they sent the herbal medicine to us through courier service,when i received the herbal medicine, I used it as he instructed

  • Camilla

    Hey! I’ve been doing quite a bit of research on this supplement over the last couple of weeks and this is probably one of the best ones out there!

    Thanks for the find and sharing, I’m alway so cautious about adding supplements into my diet because of how hard it is to find ones without all the extra bad stuff in it!

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